What is an anti-CCP test used for? The anti-CCP (anti-cyclic citrullinated peptide) test is valuable in the early detection of rheumatoid arthritis (RA) even before clinical symptoms appear. Identifying RA at this stage is crucial for early intervention and preventing extensive joint damage. These antibodies are one of the key biomarkers associated with RA, and the presence of anti-CCP antibodies in the blood can be a critical indicator of the disease, making the anti-CCP test a valuable tool for early diagnosis and appropriate treatment planning. This test looks for CCP (cyclic citrullinated peptide) antibodies in your blood. CCP antibodies can be a sign of rheumatoid arthritis. Learn more. The anti-CCP test helps detect anti-CCP antibodies, which are proteins produced by the immune system that mistakenly target the body’s own tissues, particularly proteins modified by citrullination.