Buerger's disease or thromboangitis is an inflammatory non atherosclerotic, segmental inflammatory disease affects small and medium arteries and veins of the upper and lower limbs and more common in tobacco use patients, more common in men than women< 45 years but in last decades it is prevalence between women increase may be due to increase in number of women tobacco use. There is a strong association between heavy tobacco use and the development of Buerger's disease[1]. Buerger’s disease (thromboangiitis obliterans) is a rare disease of the blood vessels in your arms, legs, fingers and toes. Inflammation in your blood vessels makes it hard for your blood to flow through them. Blood clots can form, which create obstacles inside your blood vessels. Buerger’s disease is a rare illness that almost always affects smokers. It causes pain in your hands, feet, arms, and legs. Find out more about causes, symptoms, complications, diagnosis ... Buerger's disease or thromboangiitis obliterans is a condition that reduces blood supply to the hands and feet in smokers.