Cosmopolitan definition : free from local, provincial, or national ideas, prejudices, or attachments; at home all over the world.. See examples of COSMOPOLITAN used in a sentence. cosmopolitan definition : composed of people from all over the world. Check meanings, examples, usage tips, pronunciation, domains, related words. Cosmopolitan can be an adjective, a noun, or a drink. It means containing or having experience of people and things from many different parts of the world. See how to use it in sentences and learn its pronunciation. Your Aunt Eleanor, who's lived in six different countries and speaks four languages fluently, might be described as cosmopolitan , or comfortable and familiar with different cultures and people.