Pharmacology of dobutamine , a synthetic catecholamine used as an inotrope as it is a direct-acting moderately selective β1 adrenergic agonist Dobutamine is a β 1 -agonist that increases the strength of heart contractions and cardiac output. It is used to treat acute heart failure, cardiogenic shock, and coronary artery disease stress tests. Dobutamine Injection, USP is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. Experience with intravenous dobutamine in controlled trials does not extend beyond 48 hours of repeated boluses and/or continuous infusions. Whether given orally, continuously intravenously, or intermittently ...
