Enamel , in anatomy, the hardest tissue of the body, covering part or all of the crown of the tooth in mammals. Enamel , when mature, consists predominantly of apatite crystals containing calcium and phosphate. Enamel is not living and contains no nerves. The thickness and density of enamel vary over Knowing how to protect and preserve your tooth enamel from erosion and decay begins with a basic understanding of what enamel is, how it gets damaged, and the steps you can take on a daily basis to protect it. ENAMEL definition: 1. a decorative glass-like substance that is melted onto clay, metal, or glass objects, and then…. Learn more. Enamel is the outermost layer of your teeth , playing a crucial role in protecting the delicate inner structures from damage and decay. As the hardest substance in the human body, it shields your teeth from the physical pressures of chewing and the chemical effects of acidic foods and beverages.