Hirschsprung's disease Prevalence: 1 in 3,000 births. Ultrasound diagnosis: The condition is characterized by congenital absence of intramural parasympathetic nerve ganglia in a segment of the colon. The aganglionic segment is unable to transmit a peristaltic wave, and therefore meconium accumulates and causes dilatation of the lumen of the bowel. Learn about Hirschsprung 's disease , a congenital condition that affects the nerve cells in your baby's large intestine and causes constipation or blockage. Find out how to diagnose, manage and prevent this condition and its complications. Hirschsprung (HIRSH-sproong) disease is a condition in which nerve cells are missing in a baby's large intestine, resulting in bowel blockage. These nerve cells help move contents through the colon. Without them, the contents can back up and cause problems with passing stool. Hirschsprung disease is ... Hirschsprung disease (HD) is a congenital disorder defined by the absence of ganglion cells (GC) at the Meissner's plexus of the submucosa and Auerbach's plexus of the muscularis in the terminal rectum that extends in a variable distance proximally.[1] Its prevalence varies from 1 to 1.63 per 10,000 births.[2]
