Huntington disease , an autosomal dominant inherited neurodegenerative disorder, is characterized by the clinical triad of involuntary choreiform movements with cognitive and behavioral disturbances. It occurs due to cytosine, adenine, and guanine (CAG) trinucleotide repeats on the short arm of chromosome 4p16.3 in the Huntingtin (HTT) gene. This mutation leads to an abnormally long polyglutamine expansion in the HTT protein's N-terminal fragment, which leads to neurodegeneration. The ... Huntington disease (HD) is a genetic disorder in which nerve cells in certain parts of the brain waste away, or degenerate. The disease is passed down through families. Learn about Huntington 's disease , an inherited disorder that causes nerve cells in the brain to break down and die. Find out the symptoms, diagnosis, treatment, and latest updates on this condition. Huntington disease is a hereditary disease that causes random, flowing movements that are involuntary and cannot be suppressed (called chorea). Sometimes a muscle or a group of muscles jerk (called myoclonic jerks). The disorder progresses to more pronounced involuntary movements (sometimes writhing movements, called athetosis), mental deterioration, and death.
