Although invaluable has a negative prefix, it is an adjective meaning extremely useful, indispensable or so valuable that a value can’t be set. Valuable implies a significant worth, usually in monetary terms. If you're robbed, much of what is stolen can be replaced. All you need is the cash value of what was lost. But some things––family photos, heirloom jewelry––are invaluable, meaning extremely valuable, or priceless. The meaning of INVALUABLE is valuable beyond estimation : priceless. How to use invaluable in a sentence. invaluable = valuable? Invaluable means having great value that is impossible to calculate; priceless. Find out the origin, usage, and antonyms of this adjective, as well as translations in Spanish and other languages.