Clinical Application of Genetic Linkage Enables the discovery of marker genes connected to severe dominant diseases. Genetic linkage improves the prediction of the disease's distribution in short-family pedigrees. A genetic marker would typically be a collection of alleles at a locus that is tightly linked to the specific illness gene; the closer the link, the better the marker because there is less uncertainty caused by potential gene crossover between the marker and disease genes. Genetic ... Linkage version 3.4 (DiaLinkage.exe). The number of operations needed to add a link and get it connected to other links in the mechanism has been minimized... When two or more characters of parents are transmitted to the offsprings of few generations such as F1, F2, F3 etc. without any recombination, they are called as the linked characters and the phenomenon is called as linkage. This is a deviation from the Mendelian principle of independent assortment. Mendel's law of independent assortment is applicable to the genes that are situated in separate chromosomes. When genes for different characters are located in the same chromosome, they are tied ... In linkage, two or more genes linked together are always inherited together in the same combination for more than two generations, whereas in recombination the genetic material is exchanged between different organisms which leads to the production of offsprings with the combination of traits. The chromosomal theory of inheritance came into existence long after Mendelian genetics. The lack of advanced technology and physical proof were two reasons for the rejection of Mendel’s concept of ...
