NOPE meaning : 1. no: 2. no: 3. (esp. used in spoken answers) no: . Learn more. What Does Nope Mean From a Girl? When a girl uses the term nope , it typically means the same thing as when anyone else uses it. It is a casual way to say “no” or to emphasize a negative response. Girls use it in the same way as guys and everyone else, without any specific meaning or connotation. What is the difference caused by using “ nope ” instead of ”no”? Is it used because “ nope ” sounds better and not straight like “no”? In some situations, it feels like nope is better to use than no e... Nope definition by Slang.net - The Slang Dictionary This page explains what the slang term " Nope " means. The definition , example, and related terms listed above have been manually compiled and written by the Slang.net team. We are continually updating our database with new slang terms, acronyms, and abbreviations. Want to suggest a new term or an update to this page? Let us know!