Skin pigmentation refers to the colouration of the skin, primarily determined by the presence and distribution of a pigment called melanin. Melanin is produced by specialized cells called melanocytes, located in the outermost layer of the skin known as the epidermis. What is Pigmentation on face? Pigmentation implies the bodily pigment that gives color to skin. It often results in skin discoloration. Pigmentation is the coloration of tissues by pigment or the deposition of pigment by cells. Learn more about the biological and medical aspects of pigmentation , synonyms, antonyms, and translations.