Prazosin is a medication used to treat high blood pressure and other conditions. Learn about its benefits, risks, warnings, and how to take it safely. Prazosin hydrochloride, USP a quinazoline derivative, is the first of a new chemical class of antihypertensives. The chemical name of prazosin hydrochloride, USP is 1- (4-amino-6,7-dimethoxy2-quinazolinyl)-4- (2-furoyl) piperazine monohydrochloride and its structural formula is: Prazosin is commonly used to treat high blood pressure (hypertension). Prazosin may also be used for other conditions as determined by your healthcare provider. How does prazosin work... Prazosin is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.