Senescence in plants is the same as in human beings. However, this process is essential for plants to survive. A visible example of this situation in plants is when they shed leaves during autumn. In this review, we focus on senescence-associated pathways and therapeutics understanding cellular senescence as a cascade that leads to aging, while discussing the recent details on the molecular pathways involved in regulating senescence and the benefits of therapeutic strategies against accumulated senescent cells and their secretions. Cellular senescence is a process in which cells cease dividing and undergo distinctive phenotypic alterations, including profound chromatin and secretome changes, and tumour-suppressor activation 1 – 6. Hayflick and Moorhead first introduced the term senescence to describe the phenomenon of irreversible growth arrest of human diploid cell strains after extensive serial passaging in culture 7. Later, this particular type of senescence (replicative senescence) was causally linked to telomere ... Cell senescence — a state of irreversible cell-growth arrest — has important physiological functions and is a key driver of ageing.
