Organic reactions are utilised in the production of new chemical compounds in organic synthesis. The basic chemical reactions in organic chemistry include redox reactions, rearrangement reactions, substitution reactions, addition reactions, photochemical reactions, elimination reactions, and pericyclic reactions. In this article, we will discuss the substitution reaction. It is a chemical reaction in which the replacement of atoms/groups of atoms takes place. Read on to learn more about its ... Learn about substitution reactions in organic chemistry, where one functional group is replaced by another. Find out the types, mechanisms, and examples of nucleophilic, electrophilic, and radical substitution reactions. Definition: What is a Substitution Reaction? A substitution reaction is an organic chemical reaction during which a functional group replaces an atom or another functional group attached to a carbon atom in a compound. A substitution reaction is any chemical process that replaces one atom, ion, or group in a molecule with another.