Sucralfate is indicated for short-term treatment (up to 8 weeks) of active duodenal ulcer. Learn about side effects, drug interactions, dosages, and more. Discover how Sucralfate works to treat ulcers and acid reflux. Learn about its uses, dosage, side effects, and administration tips. Consult telemedicine experts for guidance. Sucralfate is used to treat and prevent duodenal ulcers and other conditions as determined by your doctor. It works by forming a barrier or coat over the ulcer. Sucralfate is a medication for stomach ulcers, GERD, radiation proctitis, and stress ulcer prevention. It works by binding to the ulcer and protecting it from further damage, but it may cause constipation and serious side effects.