" What's up ?" is one of the most common English greetings, so it's a good idea to know how to respond when you hear it! Perfect your conversational skills with great responses to " What 's Up ?" Reply back with witty and fun quips that keep the conversation flowing. What’s up or how are you are very serious questions on Nordic cultures and are meant to be a spark for a conversation. Usually history is shared between the people who ask this question and it is further a way to connect with each other. Flirty and fun ways to respond to ' What 's up ?' From clever comebacks to charming replies, keep the conversation exciting and engaging!