Accutane (isotretinoin) is a retinoid used for severe acne, but it can cause serious birth defects and other side effects. Learn about the dosage, drug interactions, and special precautions for Accutane . Isotretinoin, also known as Accutane , is a retinoid that treats severe cystic acne, ichthyosis and some cancers. It has many side effects, including birth defects, liver failure and psychiatric problems, and requires strict controls and monitoring. Accutane (isotretinoin) is a form of vitamin A and is used to treat severe nodular acne. Includes Accutane side effects, interactions and indications. Isotretinoin (oral): side effects, dosage, interactions, FAQs, reviews. Used for: acne, acute nonlymphocytic leukemia, granuloma annulare, melanoma, metastatic, and more.