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Acetic anhydride is a carboxylic acid anhydride commonly used for the acetylation of amines and alcohols. [1] It undergoes exothermic reaction on addition of water to form acetic acid. [2] Acetic anhydride (Ac2O) is a liquid with a strong acetic acid smell (acetic acid is liberated during the hydrolysis of acetic anhydride by moisture in the air). Learn about acetic anhydride, a colorless, pungent liquid that is used as an acetylation reagent and in the manufacture of carbonic compounds. Find out how it is prepared from acetic acid, acetyl chloride, sodium acetate and other methods, and what are its chemical reactions and properties. Acetic anhydride is an acyclic carboxylic anhydride derived from acetic acid. It has a role as a metabolite and a reagent.