What is the difference between metabolic acidosis and respiratory acidosis? Metabolic acidosis involves your digestive system and your urinary system. Your kidneys can’t properly filter acids from your bloodstream. Kidney disease, kidney failure, untreated diabetes, loss of bicarbonate and blood poisoning may cause a more acidic pH in your body. Respiratory acidosis involves your respiratory system. Your lungs can’t remove enough carbon dioxide from your bloodstream. Asthma, brain ... This article delves into metabolic acidosis's biology, causes, symptoms, diagnosis, and treatment. It also briefly reviews possible preventive and self-care strategies for managing metabolic acidosis, when applicable. Metabolic acidosis happens when your blood becomes too acidic. This can result from other health conditions, such as diabetes that isn’t effectively controlled and kidney disease, among others ... Certain health conditions, prescription drugs, and dietary factors can cause acidosis. Some cases of acidosis are reversible, but without treatment, severe acidosis can be fatal.