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Acute Febrile Illness plays the role of an unexpected challenge, a quest that begins with a simple yet perplexing symptom like fever . Acute febrile illness (AFI) is a fever that subsides within three weeks without a recognized cause. Learn about the common causes, symptoms, and diagnostic methods of AFI, and how to treat it with antimalarial, antibiotic, and antiviral drugs. Acute febrile illness can be alarming. Learn about the symptoms, common causes, and effective treatment options for this condition. Get informed and stay prepared. Also, an isolated, acute febrile event in patients with a known inflammatory or neoplastic disorder is still most likely to be infectious. In healthy people, an acute febrile event is unlikely to be the initial manifestation of a chronic illness .