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Adaferin Gel is a prescription medicine used to treat acne on the face, chest, or back. It contains adapalene , a vitamin A derivative from the retinoid family. Adapalene works by reducing inflammation, preventing clogged pores, and increasing the turnover of skin cells. This helps clear blackheads, whiteheads, and pimples while also preventing new breakouts. Since only very small amounts are absorbed into the body, its effects are focused mainly on the skin’s surface. Adaferin Gel is ... Adapalene is a topical medication used to treat acne vulgaris on your skin. It works by changing how your skin cells grow and shed, and may cause side effects such as skin irritation, dryness, and sensitivity to sunlight. How to Use Adapalene Dr. King recommends applying a thin layer of the gel (about a pea-sized amount) onto clean, dry skin. Because adapalene works to both treat and prevent acne, it should be applied across the entire face, not as a spot treatment. As far as timing is concerned, adapalene, just like any other retinol, should be applied in the ... Description Adapalene is used to treat acne. It works partly by keeping skin pores clear. Adapalene is available only with your doctor's prescription.