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Addiction is a complex condition that involves compulsive use of substances or behaviors despite harmful consequences. Learn about the neurobiological, psychological, and environmental factors that contribute to addiction , and the different paths to recovery. Addiction is a condition in which a person is unable to stop using a substance or engaging in a behavior. Read on to learn more. Addiction or substance abuse is a complex brain disease. A person with an addiction experiences cravings that persist even in the face of extremely negative consequences. During a craving, a person with an addiction misses the habit-forming drug terribly, and often he or she experiences symptoms of withdrawal. Evidence strongly suggests that genetic susceptibilities and biological traits play a role in addictions; however, the development of an addiction is also shaped by a person's ...