Anguish is extreme unhappiness caused by physical or mental suffering, or the experience of an utterly free being in a world with zero absolutes. Learn about the sources, effects, and expressions of anguish in philosophy, psychology, and art. ANGUISHED definition : 1. having or showing extreme physical or mental suffering: 2. having or showing extreme physical…. Learn more. Definition of anguish noun in Oxford Advanced Learner's Dictionary. Meaning , pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Anguish is great mental suffering or physical pain. Learn the origin, pronunciation, and usage of the word anguish , and see synonyms and examples from Collins English Dictionary.