Antihistamines like Benadryl relieve allergy symptoms like sneezing and runny nose. Check out this list of common antihistamines and learn about the best options. Antihistamines are a widely used group of medications most commonly used to treat allergic conditions. Allergic conditions, such as allergic asthma, hives, and allergies themselves, occur n when ... About Antihistamines : An antihistamine drug acts against the activity of the histamine receptor — proteins that bind to a compound in the body called histamine . This compound consists of two attached to each other: ethylamine (CH3CH2NH2) and imidazole (C2N2H4), the latter being a ring. Depending on its location, histamine performs broadly four types of functions, each involving different histamine receptors called H1, H2, H3, and H4. The H1 receptor is found mostly in the inner surface of ... In this article, we will explore the pharmacology of histamines and antihistaminics, focusing on their mechanisms of action, therapeutic applications, and considerations for use.