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Ascites is a buildup of fluid in the belly, often due to severe liver disease. Learn about the causes, symptoms, diagnosis, and treatment of this condition, and how to prevent it with lifestyle changes. Ascites is a medical condition characterized by the accumulation of fluid in the abdominal cavity . This condition can be a significant indicator of underlying health issues, often related to liver disease, heart failure, or cancer. Ascites is a medical condition in which excess fluid builds up in the abdomen. This can cause a number of symptoms, including abdominal swelling, weight gain, and abdominal discomfort. Treatment for ascites depends on the underlying cause. Ascites is a buildup of fluid in the abdomen. It can happen when the liver is not working properly. Fluid fills the space between the organs and the abdominal lining, leading to swelling and pain.