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Learn what commerce is, its meaning, types, and importance in business. Check how commerce drives trade, economic growth, and global transactions in today's interconnected world. What does commerce mean? Commerce refers to the buying and selling of goods and products, especially on a large scale, as in New York City is a major center of commerce where billions of dollars are exchanged every day. The meaning of commerce, as a fundamental concept in business and economics, encompasses the exchange of goods, services, and financial transactions between individuals, businesses, or nations. Learn the meaning of commerce as the activities involved in buying and selling things, especially in large amounts. See synonyms, related words, and examples of commerce in different contexts and languages.