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Fexofenadine is an antihistamine. It is used to relieve the symptoms of hay fever (seasonal allergic rhinitis) and hives of the skin (chronic idiopathic urticaria) . Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Detailed Fexofenadine dosage information for adults and children. Includes dosages for Allergic Rhinitis and Urticaria; plus renal, liver and dialysis adjustments. Overview: Fexofenadine is an antihistamine that is taken to help treat allergy symptoms , such as a runny nose, itchy or watery eyes, sneezing, or an itchy nose or throat. Common side effects may... Fexofenadine hydrochloride is an antihistamine that helps alleviate allergy symptoms . It works by blocking histamine, a substance your body makes during an allergic reaction. This medication is commonly prescribed for conditions like allergic rhinitis and chronic urticaria (hives).