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Friedel Crafts alkylation reaction Friedel crafts alkylation reaction is the alkylation of an aromatic compound by alkyl chloride in the presence of Lewis acid or protonic acid-like AlCl 3 as a catalyst. The electron-donating groups facilitate the alkylation, while the electron-withdrawing groups hinder the alkylation. Learn the key differences, mechanisms, and applications of Friedel-Crafts alkylation and acylation for aromatic compounds. Simple explanations and solved examples for students. Friedel-Crafts Alkylation refers to the replacement of an aromatic proton with an alkyl group. This is done through an electrophilic attack on the aromatic ring with the help of a carbocation. Following an identical mechanism, two reactions, discovered by Charles Friedel and James Crafts in 1877, allow for making a new carbon–carbon bond with the aromatic ring. We can show the following general equations for the Friedel–Crafts alkylation and Friedel–Crafts acylation:
