Grignard reagent: Grignard Reaction Grignard Reagents The Grignard

Grignard Reaction Grignard Reagents The Grignard Reaction is the addition of an organomagnesium halide ( Grignard reagent ) to a ketone or aldehyde, to form a tertiary or secondary alcohol, respectively. The reaction with formaldehyde leads to a primary alcohol. Grignard Reagents are also used in the following important reactions: The addition of an excess of a Grignard reagent to an ester or lactone gives a tertiary alcohol in which two alkyl groups are the same, and the addition of a ... Reactions of Grignard reagents with epoxides, aldehydes, ketones, esters, and acid, plus the mechanism for why Grignards add twice to esters. This page takes an introductory look at how Grignard reagents are made from halogenoalkanes (haloalkanes or alkyl halides), and introduces some of their reactions. A Grignard reagent has a formula RMgX where X is a halogen, and R is an alkyl or aryl (based on a benzene ring) group. Grignard reactions and reagents were discovered by and are named after the French chemist François Auguste Victor Grignard (University of Nancy, France), who described them in 1900. [6] He was awarded the 1912 Nobel Prize in Chemistry for this work. [7] The reaction of an organic halide with magnesium is not a Grignard reaction , but provides a Grignard reagent . [8] Although Grignard reagents undergo many reactions, the classical Grignard reaction refers only to the reaction of RMgX with ...