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Abstract Human metapneumovirus (hMPV) is an emerging respiratory pathogen with a significant global health impact, especially in children, the elderly, and immunocompromised individuals. Since its identification in 2001, hMPV has been recognized as a major contributor to acute respiratory infections (ARIs), ranging from mild upper respiratory tract infections to severe lower respiratory tract illnesses such as bronchiolitis and pneumonia. This review provides a detailed overview of hMPV ... Human metapneumovirus (hMPV) is a significant global pathogen that causes acute respiratory tract infections, especially in infants, young children, the elderly, and immunocompromised individuals. Despite its increasing prevalence, there are currently no vaccines or effective treatments available for hMPV. Structure, genetic material, and replication cycle of human metapneumovirus (hMPV). (A) hMPV is a negative-sense and single-stranded RNA virus, with nine structural proteins in its genome. These ... Summary: It has been 10 years since human metapneumovirus (HMPV) was identified as a causative agent of respiratory illness in humans. Since then, numerous studies have contributed to a substantial body of knowledge on many aspects of HMPV. This ...