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Plaquenil is used to treat or prevent malaria and to treat the symptoms of rheumatoid arthritis. Learn about side effects, interactions and indications. Learn about the side effects of hydroxychloroquine, from common to rare, for consumers and healthcare professionals. Learn about hydroxychloroquine uses, dosage guidelines, side effects, and safety tips for conditions like lupus, rheumatoid arthritis, and malaria. Learn about the side effects of Plaquenil (hydroxychloroquine), from common to rare, for consumers and healthcare professionals.