Think a disease and an illness are the same thing? An internal medicine physician explains the difference. In humans, disease is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person affected, or similar problems for those in contact with the person. Learn the meaning, pronunciation and usage of the word illness, a noun for the state of being physically or mentally ill. Find out the difference between illness and disease, and see related words and collocations. 3 meanings: 1. a disease or indisposition; sickness 2. a state of ill health 3. obsolete wickedness.... Click for more definitions.