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A lipase blood test measures the amount of the enzyme lipase in your blood, which your pancreas produces to help digest fats. High or low levels may indicate pancreatic or other disorders, so see a healthcare provider if you have symptoms or abnormal results. What is a lipase test? A serum lipase test measures the amount of lipase in the body. Certain levels of lipase are necessary to maintain normal digestive and cell function. Lipase is an enzyme that helps break down fats in the body. Its levels can be measured with a serum lipase blood test. Small amounts of lipase in the blood are normal. When levels get too high, it suggests the presence of a health problem, particularly related to the pancreas, such as acute pancreatitis, which is responsible for 275,000 hospitalizations in the United States every year. A lipase test is a blood test that measures the level of a digestive enzyme called lipase in your blood. It may help diagnose or monitor problems with your pancreas, such as acute pancreatitis, cystic fibrosis, or pancreatic cancer.