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The existence of lysosomes was subtly suggested for the first time in the early 1950s by a series of experiments carried out by Nobel Prize Laureate Christian de Duve and his co-workers. These experiments were designed to identify the cellular locus of the two enzymes glucose-6-phosphatase and acid phosphatase. Liver tissue homogenates were separated into nuclear, mitochondrial, microsomal, and cytosol fractions by differential centrifugation and enzyme assays were performed on each ... Diagram of lysosomes: Lysosomes are the cell's degradation compartments and are primarily involved in the digestion of proteins, DNA, RNA, Lysosomes are spherical, membrane bound organelles that are generated by the golgi apparatus. They contain hydrolytic enzymes, and so function as part of the recycling system of the cell.In this article, we will look at the structure, synthesis and function of lysosomes, and we will consider their relevance to clinical practice. Lysosomes can be defined as the structures that are enclosed by a compartmental membrane and comprise a number of hydrolytic enzymes in its intercellular space. This post describes the definition, types, structure and functions of the lysosome.