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Minamata disease , Disease first identified in 1956 in Minamata, Japan. A fishing port, Minamata was also the home of Nippon Chisso Hiryo Co., a manufacturer of chemical fertilizer, carbide, and vinyl chloride. Methyl mercury discharged from the factory contaminated fish and shellfish, which in turn DESCRIPTION Minamata Disease (MD) is a severe neurological syndrome caused by the ingestion of seafood contaminated with methylmercury. This environmental disaster unfolded in the mid-20th century, primarily in the city of Minamata , Japan, leaving a profound mark on public health and environmental consciousness worldwide. This perspective article aims to explore the historical context, epidemiology, pathophysiology, clinical manifestations, diagnosis, treatment, and prevention strategies of MD. Minamata disease (MD) is defined as a neurological condition caused by methylmercury poisoning, characterized by sensory disturbances, cerebellar ataxia, and constriction of the visual field. Fetal Minamata disease (FMD) refers to congenital methylmercury poisoning resulting from transplacental transfer of mercury to the fetus, leading to neurological symptoms in infants born to affected mothers. AI generated definition based on: Handbook of Developmental Neurotoxicology (Second Edition), 2018 Minamata Disease is a neurological disorder caused by methylmercury poisoning from contaminated fish and shellfish. Learn about the history, causes, symptoms and measures of this pollution-related health damage in Japan, and how it affected thousands of victims and their families.