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What is the dosage for mirabegron? The recommended starting dose of mirabegron is 25 mg by mouth once daily. Mirabegron may be taken with or without food. If needed, the dose may be increased to 50 mg once daily based on individual patient response and tolerability. Coadministration of digoxin 0.25 mg with a combination of solifenacin 5 mg and mirabegron 50 mg increased digoxin AUC and peak plasma concentration by ~10% and 14%, respectively Mirabegron is a beta 3-receptor agonist. It works by activating the receptor in the bladder, causing the bladder muscles to relax. It prevents frequent, urgent or uncontrolled urination. Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Myrbetriq is a prescription medicine for overactive bladder and neurogenic detrusor overactivity. It comes in tablets or liquid and may cause high blood pressure, allergic reactions, or urinary retention.