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Blood pH Regulation Our body maintains the normal pH by acid-base balance. It is important to maintain homeostasis. There are various factors that regulate blood pH . The pH of blood plasma depends on CO 2, electrolyte and weak acid concentrations. The two main organs that regulate the acid-base balance ( pH ) of the blood are: Lungs- They are in the gaseous exchange and remove CO 2. The brain regulates breathing process so the brain and the lungs maintain blood pH by regulating the speed and ... Learn about the pH scale, the normal range of blood pH , and the causes and symptoms of high or low blood pH . Find out how to test your blood pH and what to do if it's abnormal. Learn about the pH of blood , a measure of its acidity or alkalinity, and how the body maintains it within a narrow range. Find out the causes and effects of abnormal pH levels, such as acidosis and alkalosis, and how they affect health. Key Points Blood is normally slightly basic, with a normal pH range of 7.35 to 7.45. The body maintains the pH.