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Phenytoin is used in the treatment of epilepsy, epilepsy/seizures, mania, migraine, trigeminal neuralgia and seizures. Phenytoin is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain. Learn about phenytoin mechanism of action & uses. What are normal phenytoin level & dosage. Phenytoin side effects & toxicity Phenytoin is primarily used to control seizures in epilepsy, which is a disorder that causes seizures. It may also be prescribed for other conditions as determined by a doctor. Phenytoin works by stabilizing electrical activity in the brain, which helps prevent seizures. Phenytoin is used to control seizures and prevent them during or after brain surgery. Know about its uses, dosage, side effects, and safety precautions