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Phlebitis refers to the acute inflammation of a vein and is characterized by pain, tenderness, swelling, and redness around the affected area. In most cases, inflammation is caused by a blood clot, or thrombus, and is therefore referred to as thrombophlebitis. Thrombophlebitis most often occurs in superficial leg veins, where it is called superficial thrombophlebitis, and deeper leg veins, where it is called deep vein thrombosis (DVT). Although thrombophlebitis typically affects the lower ... Phlebitis Overview Phlebitis (fle-BYE-tis) means inflammation of a vein. Thrombophlebitis is due to one or more blood clots in a vein that cause inflammation. The Facts Phlebitis means inflammation of a vein. Superficial phlebitis (also called superficial thrombophlebitis), is a condition where the veins close to the surface of the body (superficial veins) become swollen, tender, and red and develop blood clots. When deeper veins (e.g., in a muscle) develop blood clots, it's called deep vein thrombosis (DVT). Phlebitis is the inflammation of a vein, often in the legs, that can be caused by a blood clot or injury. Learn about the types, risk factors, complications, and how to treat phlebitis at home or with medical help.