PROGNOSIS meaning : 1. a doctor's judgment of the likely or expected development of a disease or of the chances of…. Learn more. 2 meanings : 1. medicine a. a prediction of the course or outcome of a disease or disorder b. the chances of recovery from a.... Click for more definitions. Prognosis was originally a medical term for the doctor's prognostication, but the word soon broadened in meaning to include predictions made by experts of all kinds. Prognosis is the likelihood or expected development of a disease, based on various factors such as diagnosis, treatment, and patient condition. Learn about the history, methodology, and estimators of prognosis , as well as its role in end-of-life decisions and advanced care planning.