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Scrub typhus, an important cause of acute fever in Asia, is caused by Orientia tsutsugamushi, an obligate intracellular bacterium. Antibiotics currently used to treat scrub typhus include tetracyclines, chloramphenicol, macrolides, and rifampicin. ... Scrub typhus should be treated with the antibiotic doxycycline. Doxycycline can be used in persons of any age. Antibiotics are most effective if given soon after symptoms begin. Learn about Scrub Typhus, its causes, symptoms, and treatment options. Discover how to prevent this bacterial infection spread by mite bites. Scrub typhus is transmitted to humans through bites from infected larval trombiculid mites known as chiggers. Symptoms include fever, headache, myalgia, and eschar. Doxycycline is the treatment of choice for patients with scrub typhus.