Serene definition: calm, peaceful , or tranquil; unruffled.. See examples of SERENE used in a sentence. Define serene . serene synonyms, serene pronunciation, serene translation, English dictionary definition of serene . adj. 1. Content or composed; untroubled: "She remained serene in the face of her accusers" . serene definition: calm and peaceful . Check meanings, examples, usage tips, pronunciation, domains, and related words. Discover expressions like "serene environment". The meaning of SERENE is marked by or suggestive of utter calm and unruffled repose or quietude . How to use serene in a sentence.