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Common causes of skin lesions include injury, infections , allergies, and autoimmune disorders. They can occur suddenly or be symptomatic of a chronic condition. 2 Most skin lesions are benign (not cancer) but they can be symptoms of life-threatening conditions like anaphylaxis. A skin infection can occur anytime your skin is broken, whether from a cut, tattoo, piercing, puncture, sting or bite. Common skin infections occurring in children and adults, with tips for prevention and maintaining healthy, radiant skin .